图片名称

mRNA/LNP检测服务

Synthgene作为全球领先的mRNA整体解决方案提供商，不仅可以提供高质量的mRNA原料，还可以提供mRNA原液和mRNA-LNP综合检测服务，支持mRNA疫苗/药物的研发和生产!

 

Synthgene可以提供多维mRNA/LNP检测服务，包括纯度，完整性，封盖率，Poly A，包封率，PDI检测等，全面评估产品的质量，安全性和生物活性。

mRNA detection service

Detection item

Detection method

Appearance

Visual method

PH

ChP 0631

mRNA sequence identity confirmation

RT-PCR

mRNA concentration

UV

mRNA Integrity

CGE/AGE

mRNA Purity(percentage of fragment mRNA)

RP-HPLC

mRNA Purity(aggregate quantitation)

SEC-HPLC

Capping rate

LC-MS

PolyA tail length

LC-MS

dsRNA

ELISA

DNA residue

qPCR

Protein residue

Nano Orange/ELISA

Plasmid purity

HPLC

Plasmid template purity

HPLC/CGE

Nucleotides and cap analogs residue

HPLC

Endotoxin

SG/DCR
mRNA-LNP detection service
Appearance Visual method
PH ChP 0631
Osmotic pressure ChP 0632
mRNA sequence identity confirmation RT-PCR
Identification and quantification of LNP components HPLC-CAD
mRNA Integrity CGE/SEC
mRNA Purity(percentage of fragment mRNA) RP-HPLC
mRNA Purity(aggregate quantitation) SEC-HPLC
Encapsulation mRNA content/Encapsulation rate RiboGreen assay
Lipid content HPLC-CAD
PS & PDI DLS
Zeta ELS
Subvisible particles Light Obscuration Particles Count Test/Microscopic Particles Count Test)
Residual solvent USP<467>、ChP 0861
Endotoxin SG/DCR
Biological activity Flow/ELISA