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Custom nucleic acid solutions
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  • GMP-Grade Core Raw Material Supply System: We supply GMP-grade mRNA synthesis raw materials, including cap analogs, modified nucleotides, NTPs, and custom monomers.

  • Full-Chain mRNA Technology Development Platform: Our platform covers the entire mRNA development chain: sequence design, plasmid prep, IVT, purification, LNP encapsulation, and product testing.

  • End-to-End One-Stop CRO Service Model: We offer end-to-end CRO services from sequence to formulation, ensuring traceability and providing IND-supporting data packages.


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HiSignal® Sequence Design Platform

AI-assisted algorithms and validated databases enable full-chain sequence engineering from target antigen design and UTR optimization to codon adaptation and structural stability assessment. Supports epitope prediction, signal peptide screening, and coupled optimization of stability and translation efficiency, delivering high-expression, low-immunogenicity candidates. Also provides gene synthesis and cloning solutions for plasmid construction.

HiSynth® Nucleic Acid Chemistry Platform

GMP-compliant supply of all mRNA synthesis raw materials, including NTPs, modified nucleotides (pseudouridine, N1-methylpseudouridine, 5-methylcytidine, etc.), and cap analogs. Supports custom modified monomers, fluorescent nucleotides, and specialty backbone derivatives. All products feature high purity, low endotoxin, and complete COA documentation.

HiTrans® IVT & Encapsulation Platform

End-to-end services from linearized plasmid preparation, IVT optimization, co-transcriptional or enzymatic capping, mRNA purification (chromatography/ultrafiltration), to LNP encapsulation. Compatible with diverse lipid formulations and microfluidics/impingement jet mixing technologies, supporting microgram-to-gram scale production. Real-time monitoring of CPPs/CQAs including particle size, PDI, encapsulation efficiency, and mRNA integrity ensures compliance with preclinical and IND requirements.

HiSignal® Analytical Platform

Comprehensive quality control for mRNA drug substance and LNP formulations, covering capping efficiency and poly(A) tail length analysis (LC-MS), integrity (CE), residual impurity testing, sterility and endotoxin, LNP characterization, encapsulation efficiency (fluorescence/RiboGreen), and in vitro activity assessment (transfection efficiency, protein expression). Supports stability study design and accelerated/long-term data generation to meet pharmacopoeia and regulatory guidelines.

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